Original Research Article I Volume 5 I Issue 1 I 2017

Comparative study between Mannitol versus Hypertonic saline continuous infusion versus Hypertonic saline boluses in treatment of edema of traumatic brain injury

Mohamed Mustafa Abd El-Salam Megahed; Sherif Abd El-Fattah Shehata; Mohamed Yousef Mahmoud Gad

Biolife; 2017, 5(1), pp 111-117

DOI:https://doi.org/10.5281/zenodo.7360723

Abstract:

Severe brain edema that is not successfully treated can lead to progressive intracranial hypertension, cerebral ischemia, brain herniation, and progression to death. Many studies have shown that hypertonic saline may be effective in treatment of all kinds of cerebral edema and intracranial hypertension caused by various causes, including traumatic brain injury.

Keywords:

Mannitol, Hypertonic saline continuous infusion, hypertonic saline boluses, brain edema.

References:

  1. Adamides AA, Cooper DJ, Rosenfeldt FL, Bailey MJ, Pratt N, Tippett N, et al. Focal cerebral oxygenation and neurological outcome with or without brain tissue oxygen-guided therapy in patients with traumatic brain injury. Acta Neurochir 2009; 151:1399-409.
  2. Nag S, Manias JL, Stewart DJ. Pathology and new players in the pathogenesis of brain edema. Acta Neuropathol 2009; 118:197-217.
  3. Marmarou A. A review of progress in understanding the pathophysiology and treatment of brain edema. Neurosurg Focuss 2007; 22(5):E1.
  4. Pérez-Pérez AJ, Pazos B, Sobrado J, Gonzalez L, Gándara A. Acute renal failure following massive mannitol infusion. Am JNephrol 2002; 22:573-5.
  5. Dziedzic T, Szczudlik A, Klimkowicz A, Rog TM, Slowik A. Serum albumin level and nosocomial pneumonia in stroke patients. Eur J Neurol 2006; 13(3):299-301.
  6. GondimFde A, Aiyagari V, Shackleford A, Diringer MN. Osmolality not predictive of mannitol-induced acute renal insufficiency. J Neurosurg 2005; 103:444-7.
  7. Suarez JI. Hypertonic saline for cerebral edema and elevated intracranial pressure. Cleve Clin J Med 2004; 71(1):9-13.
  8. Diringer MN, Zazulia AR. Osmotic therapy: Fact and fiction. Neurocrit Care 2004; 1:219-33.
  9. Kerwin AJ, Schinco MA, Tepas JJ, Renfro WH, Vitarbo EA, Muehlberger M. The use of 23.4% hypertonic saline for the management of elevated intracranial pressure in patients with severe traumatic brain injury: a pilot study. J Trauma 2009; 67:277-82.
  10. Hauer EM, Stark D, Staykov D, Steigleder T, Schwab S, Bardutzky J. Early continuous hypertonic saline infusion in patients with severe cerebrovascular disease. Crit Care Med 2011; 39:1766-72.
  11. Vialet R, Albane`se J, Thomachot L, Harutjunyan L, Holz C, Rieger A, et al. Isovolume hypertonic solutes (sodium chloride or mannitol) in the treatment of refractory posttraumatic intracranial hypertension: 2 mL/kg 7.5% saline is more effective than 2 mL/kg 20% mannitol. Crit Care Med 2003; 31:1683-7.
  12. Harutjunyan L, Holz C, Rieger A, MenzeM, GrondS, Soukup J. Efficiency of 7.2% hypertonic saline hydroxyethyl starch 200/0.5 versus mannitol 15% in the treatment of increased intracranial pressure in neurosurgical patients-A randomized clinical trial. Crit Care 2005; 9:R530-54...

Article Dates:

Received: 6 January 2017; Accepted: 27 February 2017; Published: 5 March 2017

How To Cite:

Mohamed Mustafa Abd El-Salam Megahed, Sherif Abd El-Fattah Shehata, & Mohamed Yousef Mahmoud Gad. (2022). Comparative study between Mannitol versus Hypertonic saline continuous infusion versus Hypertonic saline boluses in treatment of edema of traumatic brain injury. Biolife, 5(1), 111–117. https://doi.org/10.5281/zenodo.7360723

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