Original Research Article I Volume 2 I Issue 1 I 2014
COMPUTATIONAL STUDY OF CYCLIC DERIVATIVES FROM PYRIDINE-4-CARBOXYLIC ACID AS POTENTIAL ANTI-TB AGENTS
Kandukuri Usha Rani; Padmavathi, D.A
Biolife; 2014, 2(1), pp 392-395
DOI:https://dx.doi.org/10.5281/zenodo.7198316
Abstract:
Mycobacterium tuberculosis, the causative agent of tuberculosis (TB), is a remarkably successful pathogen that has latently infected a third of the world population. The objective is to model new molecular scaffolds by re- engineering and repositioning old drug families. Existing TB drugs isoniazid, thioamides belonging to the class of pyridine 4-carboxylic acid were substituted with an allyl or Propargylic groups at 2,6 positions. Molecular modeling tool is used to check and compare the structure and stability of existing TB drugs isoniazid, thioamides along with newly proposed molecules 2-Allyl Isoniazid, 2-Propargyl Isoniazid and 6-Alloyl Thioamides.
Keywords:
Cyclic derivatives, Mycobacterium tuberculosis, anti-TB agents, Pyridine-4-carboxylic acid
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Article Dates:
Received: 14 January 2014; Accepted: 26 February 2014; Published: 10 March 2014
How To Cite:
Kandukuri Usha Rani, & Padmavathi, D.A. (2022). OMPUTATIONAL STUDY OF CYCLIC DERIVATIVES FROM PYRIDINE-4-CARBOXYLIC ACID AS POTENTIAL ANTI-TB AGENTS. Biolife, 2(1), 392–395. https://doi.org/10.5281/zenodo.7198316
