Original Research Article I Volume 2 I Issue 1 I 2014

ALKALINE PHOSPHATASE AND ACID PHOSPHATASE LEVELS IN THE ABDOMINAL MUSCLES OF IMMUNOSTIMULATED MICE DURING HEPATITIS B

Madhuri D; VivekaVardhani V

Biolife; 2014, 2(1), pp 335-340

DOI:https://doi.org/10.5281/zenodo.7197397

Abstract:

The investigations were conducted in 8 groups of male Swiss Albino mice (6-8 wks old; 23-26 g wt). In mice of group I (10), Immunex DS (IDS) was orally administered (@150mg/mouse) as a single dose. In mice (10) of group A, B, C, D, E and F, IDS was given orally @150mg/mouse (single dose) (on day 0) and Gene Vac B vaccine was infected on day 4 of experiment @ 0.07ml/mouse, 0.1ml/mouse, 0.2ml/mouse 0.4ml/mouse, 0.8ml/mouse and 1ml/mouse. Another group (U) of mice (10) was kept untreated (with IDS and uninfected) as controls for comparison.

Keywords:

ALP, ACP, Abdominal muscles, Mice, Immunostimulant, Hepatitis.

References:

 1.      Beis, I. and Newsholme, E. A. 1975. The contents of adenine nucleotides, phosphagens and some glycolytic intermediates in resting muscles from vertebrates and invertebrates.  Biochem. J. 152(1): 23-32.

2.      Bessey, O. A., Lowry, O. H. and Brock, M. J. 1946. Method for the rapid determination of alkaline phosphatase with 5 cubic millimeters of serum.  J. Biol. Chem. 164: 321-329.

3.      Chu, T. M. and Lin, M. F. 1998. PSA and acid phosphates in the diagnosis of prostate cancer. J. Clin. Ligand Assay. (21): 24-34.

4.      Chen, K. T.,  Malo, M. S.,  Moss, A. K.,  Zeller, S.,  Johnson, P.,  Ebrahimi. F.,  Mostafa, G., Alam, S. N.,  Ramasamy, S., Warren, H. S.,  Hohmann, E. L. and Hodin, R. A. 2010. Identification of specific targets for the gut mucosal defense factor intestinal alkaline phosphatase. Am. J. Physiol Gastrointest . Liver Physiol. 299(2): G467 - G475.

5.      Ekanem,  J. T. 2005. Activities of alkaline phosphatase, glutamate oxaloacetate transaminase and glutamate pyruvate transaminase in liver and serum of Trypanosoma brucei - infected rats treated with honey. Biochem. 17(2): 185-191.

6.      Guidotti, L. G., Ishikawa, T., Hobbs, M. V., Matzke, B., Schreiber, R. and Chisari, F. V. 1996. Intracellular inactivation of the hepatitis B virus by cytotoxic T lymphocytes. Immunity, 4 (1): 25-36.

7.      Lavanchy, D. 2004. Hepatitis B virus epidemiology, disease burden, treatment and current and emerging prevention and control measures. J. Viral Hepatol. 11(2): 97-107.

8.      Lyon , J. B. and Porter, J. 1963. The relation of phosphorylase to glycogenolysis in skeletal muscle and heart of mice. J.  Biol. Chem. 238(1): 1-11.

9.      Marrero, M., Prough, R. A., Frenkel, R. A. and Milewich, L. 1990. Dehydroepiandrosterone feeding and protein phosphorylation, phosphatases, and lipogenic enzymes in mouse liver. Proc. Soc. Exp. Biol. Med. 193(2): 110-117.

10.  Milich, D. and Liang, J. T. 2003. Exploring the Biological basis of hepatitis B e antigen in hepatitis B virus infection.  Hepatol.  38(5): 1075-1086.

11.  Narisawa, S.,  Huang, L.,  Iwasaki, A., Hasegawa, H., Alpers, D. H. and  Millian, J. L. 2003. Accelerated fat absorption in intestinal alkaline phosphatase knockout mice. Mol. Cell Biol. 23 (21): 7525-7530.

Article Dates:

Received: 12 January 2014; Accepted: 27 February 2014; Published: 5 March 2014

How To Cite:

Madhuri D, & VivekaVardhani V. (2022). ALKALINE PHOSPHATASE AND ACID PHOSPHATASE LEVELS IN THE ABDOMINAL MUSCLES OF IMMUNOSTIMULATED MICE DURING HEPATITIS B. Biolife, 2(1), 335–340. https://doi.org/10.5281/zenodo.7197397

Download Full Paper: PDF

Logo


Logo