Original Research Article I Volume 11 I Issue 1 I 2023

Thujone in Daily Life – A Review on Natural Sources of Thujone, its Side Effects and Reduction Mechanism of Thujone Toxicity

Swapnil Pal, Avijit Dey

Biolife, Volume 11, Issue 1, 2023, pp 21-31

DOI:https://doi.org/10.5281/zenodo.7698494

Abstract:

Thujone is a natural or manmade ketone monoterpenoid, fragment substance which is most famous for its use in absinthe spirit. It is found in various plants which are used as medicines, foods, hard drinks, and for various purposes in our daily life. The plants that contain thujone are wormwood, clary, tansy, sage, some junipers, oregano, thuja, cypress, mentha, lavender, etc. So it is likely to use thujone-containing plants for food and medicine can be harmful to our body. It has been reported that long-term use of these plants may leads to diseases like stomach aches, seizures, renal failure, hallucination, rhabdomyolysis, paralysis and even death. In current review we have discussed different toxic effects of thujone and have tried to search the plausible solutions by which we can minimize or remove the thujone from daily used plant products.

Keywords:

Thujone, Plants, Foods, Medicine, Toxicity, Reductio

References:

  1. Emmert, J., Sartor, G., Sporer, F., & Gummersbach, J. (2004). Determination of alpha-/beta-thujone and related terpenes in absinthe using solid phase extraction and gas chromatography. DEUTSCHE LEBENSMITTELRUNDSCHAU, 352-356.
  2. Wróblewska-Kurdyk, A., Gniłka, R., Dancewicz, K., Grudniewska, A., Wawrzeńczyk, C., & Gabryś, B. (2019). β-thujone and its derivatives modify the probing behavior of the peach potato aphid. Molecules, 24(10), 1847.
  3. Akkol, E. K., İlhan, M., Demirel, M. A., Keleş, H., Tümen, I., & Süntar, İ. (2015). Thuja occidentalis L. and its active compound, α-thujone: Promising effects in the treatment of polycystic ovary syndrome without inducing osteoporosis. Journal of ethnopharmacology, 168, 25-30.
  4. Judzentiene, A., Budiene, J., Gircyte, R., Masotti, V., & Laffont-Schwob, I. (2012). Toxic Activity and Chemical Composition of Lithuanian Wormwood (Artemisia absinthium L.) Essential Oils. Records of Natural Products, 6(2).
  5. Pappas, R., & Sheppard-Hanger, S. (2000). Artemisia arborescens-essential oil of the Pacific Northwest: a high-chamazulene, low-thujone essential oil with potential skin-care applications. Aromather. J, 10, 30-33.
  6. Halicioglu, O., Astarcioglu, G., Yaprak, I., & Aydinlioglu, H. (2011). Toxicity of Salvia officinalis in a newborn and a child: an alarming report. Pediatric neurology, 45(4), 259-260.
  7. Rivera, E. M., Cid, M. P., Zunino, P., Baiardi, G., & Salvatierra, N. A. (2014). Central α-and β-thujone: similar anxiogenic-like effects and differential modulation on GABAA receptors in neonatal chicks. Brain research, 1555, 28-35.
  8. Höld, K. M., Sirisoma, N. S., & Casida, J. E. (2001). Detoxification of α-and β-Thujones (the active ingredients of absinthe): site specificity and species differences in cytochrome P450 oxidation in vitro and in vivo. Chemical research in toxicology, 14(5), 589-595.
  9. Albert-Puleo, M. (1978). Mythobotany, pharmacology, and chemistry of thujone-containing plants and derivatives. Economic Botany, 32(1), 65-74.
  10. Radulović, N. S., Genčić, M. S., Stojanović, N. M., Randjelović, P. J., Stojanović-Radić, Z. Z., & Stojiljković, N. I. (2017). Toxic essential oils. Part V: Behaviour modulating and toxic properties of thujones and thujone-containing essential oils of Salvia officinalis L., Artemisia absinthium L., Thuja occidentalis L. and Tanacetum vulgare L. Food and Chemical Toxicology, 105, 355-369.
  11. Lachenmeier, D. W., Nathan-Maister, D., Breaux, T. A., & Kuballa, T. (2009). Long-term stability of thujone, fenchone, and pinocamphone in vintage preban absinthe. Journal of agricultural and food chemistry, 57(7), 2782-2785.......

Article Dates:

Received: 29 Decemb er 2022; Accepted: 21 February 2023; Published online: 4 March 2023.

How To Cite:

Swapnil Pal, & Avijit Dey. (2023). Thujone in Daily Life – A Review on Natural Sources of Thujone, its Side Effects and Reduction Mechanism of Thujone Toxicity. Biolife, 11(1), 21–31. https://doi.org/10.5281/zenodo.7698494

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