Original Research Article I Volume 3 I Issue 4 I 2015

Protective role of flaxseed oil on hypercholesterolemic rats

Mohamed M. Aly-Aldin; Esam H. Mansour; Elsayed H. Rahma; E. El-Beltagy Abo El-Fath A. ElBedawey; Magida M. El-Habashy

Biolife; 2015, 3(4), pp 794-801

DOI:https://doi.org/10.5281/zenodo.7302710

Abstract:

The present study aims to investigate the effects of replacing corn oil content (10%) in the standard diet of hypercholesterolemic rats (fed standard diet + 2% cholesterol for 4 weeks) with 50, 75 and 100% levels of flaxseed oil on the body weight gain, organ weight, blood glucose, liver and kidney functions and lipid profile. Data showed that 2% cholesterol administration caused significant increase in glucose, ALT, AST, ALP, urea, uric acid, triglyceride, total lipids, total cholesterol, LDL and VLDL levels in serum of hypercholesterolemic rats.

Keywords:

Flaxseed oil, hypercholesterolemic rats, lipid profile, liver functions, kidney functions

References:

  1. Al-Bishri, W.M. 2013. Favorable effects of flaxseed supplemented diet on liver and kidney functions in hypertensive rats. Journal of Oleo Science, 62: 709-715.
  2. Allian C., Poon L., Richmond W., Fu P. 1974. Enzymatic determination of total serum cholesterol. Clin Chem, 20: 470-475.
  3. Anwar M., Meki A. 2003. Oxidative stress in streptozotocin-induced diabetic rats: effects of garlic oil and melatonin. Comparative Biochem Physiol, 135: 539-547.
  4. Barakat, L.A.A., Mahmoud, R.H. 2011. The antiatherogenic, renal protective and immunomodulatory effects of purslane, pumpkin and flax seeds on hypercholesterolemic rats. North American Journal of Medical Sciences, 3: 351-357.
  5. Barcelo-Coblijn, G., Murphy, E.J. 2009. Alpha-linolenic acid and its conversion to longer chain n-3 fatty acids: benefits for human health and a role in maintaining tissue n-3 fatty acid levels. Progress in Lipid Research, 48:355-374.
  6. Barham, D., Trinder, P. 1972. Quantitative enzymatic colorimetric determination of uric acid in serum, plasma or urine. Analyst, 97: 142-145.
  7. Burstein, M., Scholnik, H., Morfin, R. 1970. Rapid method for the isolation of lipoproteins from human serum by precipitation with polyphenols. J lipid Res, 11: 583-595.
  8. Chapman, D.G., Castilla, R., Campbell, J.A. 1959. Evaluation of protein in foods: 1. A method for the determination of protein efficiency ratios. Canadian J. of Biochemistry and Physiology, 37: 679-686.
  9. Cohen S., Moore A., Ward W. 2005. Flaxseed oil and inflammation –associated bone abnormalities in interleukin 10 Knockout mice. The Journal of Nutritional Biochemistry, 16: 368-374.
  10. Drury, R.A., Wallington, E.A. 1980. Carton’s Histological Technique, 5th Ed., Oxford Univ. London, U.K.
  11. EL-Sahar, E.G.E., Abed EL- Rahman, A.M.M. 2014. Study on the biological effect of use flaxseed oil as a source of fat on the Biomarkers of experimental rats. Journal of American Science, 10: 116-123.
  12. El-Sayed, H.H., Darwish A.H., Ysein, E.M., Zehairy G.D. 2014. Biochemical and biological study on the effect of flaxseed on rats Suffer from nephropathy. Journal of Environmental Science, Toxicology and Food Technology, 8: 59-66...

Article Dates:

Received: 3 October 2015; Accepted: 18 November 2015; Published: 5 December 2015

How To Cite:

Mohamed M. Aly-Aldin, Esam H. Mansour, Elsayed H. Rahma, E. El-Beltagy Abo El-Fath A. ElBedawey, & Magida M. El-Habashy. (2022). Protective role of flaxseed oil on hypercholesterolemic rats. Biolife, 3(4), 794–801. https://doi.org/10.5281/zenodo.7302710

Download Full Paper: PDF
Submit Manuscript
Join as Reviewer / Editor

Logo


Logo