Original Research Article I Volume 11 I Issue 1 I 2023

Biochemical Investigations on the In Vitro Effect Of Praziquantel on The Acetylcholine Esterase of the Cattle Parasite Paramphistomum epiclitum

Narsaiah Shivakoti

Biolife, Volume 11, Issue 1, 2023, pp 43-46

DOI:https://doi.org/10.5281/zenodo.7703289

Abstract:

Paramphistomiasis or Amphistomiasis is a neglected tropical disease, caused by Paramphistomum species in livestock ruminants and wild mammals. Its symptoms include profuse diarrhea, anemia, and lethargy, and often result in death if untreated. It causes significant economic loss in livestock production, as it can reduce feed efficiency, increase weight, and affect milk production. The life cycle of a parasite is indirect, requiring a definitive host such as ruminants, and an intermediate host such as snails. To treat this disease, a wide range of Anthelmintic drugs with different types of mechanisms of action are available, among which Praziquantel (Biltricide, Droncit) is one of them. Understanding the mechanism of action of a drug on parasites gives better scope for the development of a wide range of effective drugs. Several drug target action sites are identified in parasites among which acetylcholine esterase (Ache) is one of them. It plays a crucial role in the regulation of nerve impulses by breaking down the neurotransmitter acetylcholine into acetic acid and choline in the synaptic cleft. In the current paper Praziquantel mode of action on Ache activity in Paramphistomum epiclitum is studied.

Keywords:

Praziquantel, Acetylcholine esterase, Paramphistomum epicitum, Anthelmintics, Ion channel

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Article Dates:

Received: 14 January 2022; Accepted: 18 February 2023; Published online: 7 March 2023.

How To Cite:

Narsaiah Shivakoti. (2023). Biochemical Investigations on the In Vitro Effect Of Praziquantel on The Acetylcholine Esterase of the Cattle Parasite Paramphistomum epiclitum. Biolife, 11(1), 43–46. https://doi.org/10.5281/zenodo.7703289

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