Original Research Article I Volume 4 I Issue 2 I 2016

Fluid balance in critically ill patients, prospective observational study

Tayseer Muhammad Zaytoun; Amr Hassan Dahroug; Ibrahim Sabri

Biolife; 2016, 4(2), pp 265-270.



Introduction: fluid balance has recently emerged as a potential biomarker for survival in critically ill patients. Objectives: To assess the prognostic value of daily and cumulative fluid balance on mortality in the first five days for patients admitted due to critical illness. Methods: The study was conducted on 455 adult patients admitted to Critical Care Medicine Department units at Alexandria Main University Hospital with different critical diagnosis during six months from 1st January 2015 to end of June 2015.


Fluid balance, Critical illness, Mortality.


  1. Bagshaw SM, Brophy PD, Cruz D. Fluid balance as a biomarker: impact of fluid overload on outcome in critically ill patients with acute kidney injury. Crit Care 2008; 12:169.
  2. Kellum JA, Song M, Venkataraman R. Effects of hyperchloremic acidosis on arterial pressure and circulating inflammatory molecules in experimental sepsis. Chest 2004; 125:243-8.
  3. Brandstrup B, Tonnesen H, Beier-Holgersen R, Hjortsø E, Ørding  H,  Lindorff-Larsen K, et al. Effects of intravenous fluid restriction on postoperative complications: comparison of two perioperative fluid regimens: a randomized assessor blinded multicenter trial. Ann Surg 2003;238:641-8.
  4. Sakr Y, Vincent JL, Reinhart K, Groeneveld J, Michalopoulos A, Sprung CL, et al. High tidal volume and positive fluid balance are associated with worse outcome in acute lung injury. Chest 2005;128:3098-108.
  5. Wiedemann HP. Comparison of two fluid-management strategies in acute lung injury. N Engl J Med 2006;354:2564-75.
  6. Vincent JL, Sakr Y, Sprung CL, Ranieri VM, Reinhart K, Gerlach H, et al. Sepsis in European intensive care units: results of the SOAP study. Crit Care Med 2006;34:344-53.
  7. Upadya A, Tilluckdharry L, Muralidharan V, Amoateng-Adjepong Y, Manthous CA. Fluid balance and weaning outcomes. Intensive Care Med 2005;31:1643-7.
  8. Alsous F, Khamiees M, DeGirolamo A, Amoateng-Adjepong Y, Manthous CA. Negative fluid balance predicts survival in patients with septic shock: a retrospective pilot study. Chest. 2000;117:1749–54.
  9. Sirvent JM, Ferri C, Baro A, Murcia C, Lorencio C. Fluid balance in sepsis and septic shock as a determining factor of mortality. Am J Emerg Med. 2015;33:186–9.
  10. de Oliveira FS, Freitas FG, Ferreira EM, de Castro I, Bafi AT, de Azevedo LC, et al. Positive fluid balance as a prognostic factor for mortality and acute kidney injury in severe sepsis and septic shock. J Crit Care. 2015;30:97–101.
  11. Abulebda K, Cvijanovich NZ, Thomas NJ, Allen GL, Anas N, Bigham MT, et al. Post-ICU admission fluid balance and pediatric septic shock outcomes: a risk-stratified analysis. Crit Care Med. 2014;42:397–403.

Article Dates:

Received: 4 April 2016; Accepted: 19 May 2016; Published: 3 June 2016

How To Cite:

Tayseer Muhammad Zaytoun, Amr Hassan Dahroug, & Ibrahim Sabri. (2022). Fluid balance in critically ill patients, prospective observational study. Biolife, 4(2), 265–270. https://doi.org/10.5281/zenodo.7317726

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